Postdoctoral Research Position: Neurophysiology in vitro, Marseille, France

A postdoctoral position is available with Dr. Dominique Debanne at

INSERM U641, Marseille, France(http://ifrjr.nord.univ-mrs.fr/-equipe-4,89-).

Applicants should have solid experience of in vitro electrophysiologica l recording techniques (patch-clamp) and, analysis of synaptic transmission and neuronal excitability. The successful applicant will combine multiple electrophysiologica l measurements, neuronal transfection, pharmacology and dynamic-clamp in brain slices to study the function and plasticity of hippocampal GABAergic networks in the context of epilepsy.

Eligibility: PhD with excellent training in electrophysiology. Knowledge or experience in neuronal transfection (gene-gun, viral transfection) and imaging techniques would be highly desirable without being mandatory.

Duration: Post
funded by ANR (starting 1st April 2010, 24
months with a possible extension).

Salary: 24
150EUR / year net


Selected Publications of the Team:
Debanne et al. (2008) Nature Protocols 3: 1559-1568
Campanac et al. (2008) J Neurosci 28: 8635-8643
Campanac & Debanne (2008) J Physiol 586: 779-793
Boudkkazi et al. (2007) Neuron 56: 1048-1060
Carlier et al. (2006) J Physiol 577: 141-154


Applicants should submit a CV and two references to:

Dr. Dominique Debanne
INSERM U641 - Neurobiologie des Canaux Ioniques
Faculté de Médecine- Secteur Nord
Université de la Méditerranée
CS80011
Boulevard Pierre Dramard
F-13344 Marseille cedex 15
France

Tel: +33 (0)4 91 69 87 45
Fax: +33 (0)4 91 09 05 06
e-mail: dominique.debanne@ univmed.fr

Post-doc Position in bio technology, France

Post-doc Position in bio technology, France

The Institute of Structural Biology (IBS) in Grenoble and the Laboratory LEGI
collaborate within the project Nanobiodrop.

This project involves the formation of artificial biological membranes to study the insertion of transmembrane transport proteins and measure their activity. The technique based on the manipulation of nanodroplets has proven effective in vitro and its integration into micro systems is a challenge today that opens interesting perspectives in biotechnology and biology such as drug screening or the study
of artificial cells networks.

The objectives of the postdoctoral position are to associate in a microsystem :
{ The formation of biological membranes by microfuidic techniques.
{ The insertion of transmembrane proteins studied at the IBS (ion channels and transporters) .
{ The measurement of transport activity of these proteins by electrophysiologica l or optical means.
{ The possibility of creating a network of interconnected membranes by transmembrane proteins.

The ideal candidate is a biophysicist, with a knowledge of, or a desire to learn, standard microfabrication techniques. Expertise in fluidics, surface treatment, membrane protein biochemistry and/or electrophysiology will be an asset.

The proposed contract is for two years. It is funded by the French network RTRA "Nanosciences" and the collaborative program in Physics, Chemistry and Biology of the CNRS "Support for risk taking". The candidate will work under the supervision of both LEGI and IBS and will benefit from access to state-of-the-art resources in all aspects of the project.

The candidate should have defended his PhD thesis for less than three years and a part of his scientific training has been done outside of France.

Salary : EUR2300 ¤/month
Contacts :
Benjamin Cross : benjamin.cross@ legi.grenoble- inp.fr
Michel Vivaudou :michel.vivaudou@ cea.fr